I’ve been playing around with Brizzly this morning, and here are some initial thoughts. My default Twitter app is Tweetdeck, so I’m comparing to that.
But here’s the major change that Brizzly introduces, and for me, a concern:

My reply with a comment about the cat shows up (for me, in Brizzly) – right under the photo. So the context of my comment is very clear to me. However, for the recipient, if she uses another Twitter app, my reply will show as a usual @ tweet in her stream.
The problem is that for me, the context is very clear, but for her, it may be confusing. If I reply “awww…. !” she has to put 2+2 together to figure what my tweet is about. I usually try to include context in my tweets – I’d usually reply “awww… cute cat!” – so she knows that the tweet is about. I try to avoid using “this” and “that” in tweets and instead specify what I’m referring to.
I posted a photo, and people’s comments didn’t show under the photo, like in Twitpic, but just as replies in my twitter stream – so no context there for me on the receiving side.
It’s confusing to have context for some people, in some instances, but not for others. If some people use Brizzly and others don’t, I can see a lot of misscommunication happening on Twitter.
Although Brizzly might enhance MY Twitter experience, the confusion about context might reduce the overall community experience.
Watch the Brizzly demo:
Sphere: Related Content
In Twitter, the “@*****” seems like the source code. I have a feeling that I am operating Linux when I type the hashtags. Brizzly seems like a stand-alone software or like Windows providing more visual components for helping people experience Twitter better. At the mention of Facebook, its comment system should add the “Relpy” link after each name in the list of comments. So that user can pick up the one who he/she wants to reply instead of many “omnidirectional” comments.